Lauric Arginate is the term that has been accepted by the Food and Drug Administration (FDA) for labelling purposes of Ethyl lauroyl arginate HCl. Other names commonly used to refer to this substance are LAE® and Lauroyl arginine ethyl ester HCl.

Ethyl lauroyl arginate HCl is a synthetically produced cationic substance manufactured in LAMIRSA GROUP premises, according to processes patented by the company. The main particularity of Ethyl lauroyl arginate is that its building blocks are naturally occurring substances: L-arginine, ethanol and lauric acid. Once Ethyl lauroyl arginate HCl is ingested by consumers, it is easily hydrolysed within a few minutes in the human body into natural compounds commonly found in the diet. This property is not shared by the other food preservatives currently found in the marketplace such as sorbates, benzoates, sulphites, nitrites and nitrates.

Effective against Gram positive and Gram negative bacteria, yeasts and moulds

Ethyl lauroyl arginate HCl is effective as a preservative against bacteria, yeast and moulds in a wide range of food and cosmetic products because it is able to disrupt the integrity of the cell membranes of these microorganisms (J. Appl. Microbiol., 2004, 96 (5) 903-912). Efficacy shown through out MIC’s (Minimum Inhibitory Concentration) is high. For instance, against Gram positive and Gram negative bacteria MIC’s are between 8 and 64 μg/ml as an average, and against yeast and mould are between 16 and 128 μg/ml. In spite of those MIC values, the doses of application of LAE® in the final food and cosmetic products are usually higher. This is due to the differences in composition, conditions and requirements that those products have compared to the one of an in vitro test.

Investigations have proved that Ethyl lauroyl arginate HCl causes the inactivation or neutralisation of the endotoxins released by Gram negative bacteria, such as Escherichia coli, which might mitigate the damage caused by endotoxins in animals and human beings.

Safe and effective products for the treatment of viral infections are constantly needed. In this sense, VEDEQSA commissioned several investigations to study the efficacy of Ethyl lauroyl arginate HCl against certain viruses. The results of these investigations proved a strong antiviral activity against viruses of Vaccinia, Herpes simplex and bovine parainfluenzae virus types.

VEDEQSA highlights the fact that Ethyl lauroyl arginate HCl has applications in cosmetics as an active ingredient as well as a preservative.

The following tables show the MIC’s values of LAE® against different types of microorganisms, also pathogens, which gives an insight into LAE® wide range of activity and great effectiveness. The results were obtained by Dr. Manresa, from the Facultat de Farmàcia of Universitat de Barcelona:

GRAM POSITIVE BACTERIA

LAE®

(µg/ml)

Alicyclobacillus acidiphilus DSMZ 14558

8

Arthrobacter oxydans ATCC 8010

64

Bacillus cereus var mycoide ATCC 11778

32

Bacillus subtilis ATCC 6633

16

Clostridium botulinum ATCC 19397

64

Clostridium estertheticum  ATCC 51377

32

Clostridium perfringens ATCC 77454

16

Clostridium perfringens ATCC 12917

16

Lactobacillus curvatus ATCC 25601

16

Lactobacillus delbrueckkii ssp lactis ATCC 10705

16

Lactobacillus paracasei ATCC 25302

16

Lactobacillus plantarum ATCC 8014

16

Listeria monocytogenes B4/97 [1]

8

Listeria monocytogenes ATCC 15313

32

Leuconostoc mesenteroides ATCC 19255

32

Microccocus luteus ATCC 9631

128

Mycobacterium phlei ATCC 41423

2

Staphylococcus aureus ATCC 6538

8

GRAM NEGATIVE BACTERIA 

LAE®

(µg/ml)

Alcaligenes faecalis ATCC 8750

64

Bordetella bronchiseptica ATCC 4617

128

Campylobacter jejuni ATCC 29428

8

Citrobacter freundii ATCC 22636

64

Enterobacter aerogenes ATCC 13048

32

Enterobacter faecalis ATCC 27285

4

Enterobacter sakazakii ATCC 29544

32

Escherichia coli 0157H7 ATCC 35150

32

Escherichia coli ATCC 8739

32

Klebsiella pneumoniae var pneumoniae ATCC 4352

32

Proteus mirabilis CECT 170

32

Pseudomonas aeruginosa ATCC 9027

32

Pseudomonas fluorescens ATCC 13430

32

Salmonella choleraesuis ATCC 13076

8

Salmonella typhimurium ATCC 14028

32

Shigella dysentariae ATCC 13313

8

Serratia marcescens ATCC 10759

32

Yersinia enterocolitica ATCC 27729

16

Vibrio parahaemolyticus ATCC 17802

128

YEASTS

LAE®

(µg/ml)

Candida albicans ATCC 10231

16

Rhodotorula rubra CECT 1158

16

Saccharomyces cerevisiae ATCC 9763

32

MOULDS

LAE®

(µg/ml)

Aspergillus niger ATCC 14604

32

Aureobasidium pullulans ATCC 9348

16

Glicocladium virens ATCC 4645

32

Chaetomium globosum ATCC 6205

16

Penicillium chrysogenum ATCC 9480

128

Penicillium funiculosum CECT 2914

16

[1] Isolated from polluted meat by Microbiology Unit, Facultat de Farmàcia, Universitat de Barcelona.

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